Practice Guidelines Add a new review Multicentre, cluster-randomized clinical trial of algorithms for critical-care enteral and parenteral therapy (ACCEPT). Posted By:Gordon S. Doig Summary of Recommendations from the Canadian Asthma Consensus Report, 1999 Posted By:The Seat of Our Pants Discussion Group  Link to other CMAJ guidelines  By:Gord Recommendations for the Management and Treatment of Dyslipidemia Posted By:LDS, JJT, JSMW, JKC (UWO)

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Economic Analysis Add a new review A prospective, randomized study comparing percutaneous with surgical tracheostomy in critically ill patients. Posted By:Gord Doig

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Outcome Variations Add a new review Impact of restricting fluoroquinolone prescription on bacterial resistance in an intensive care unit. Posted By:Gordon S. Doig A Before and After Trial of The Effect of a High-Dependency Unit on Post-Operative Morbidity and Mortality Posted By:Gordon S. Doig Admission to a neurologic/neurosurgical intensive care unit is associated with reduced mortality rate after intracerebral hemorrhage Posted By:Gordon S. Doig

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Utilization Review Add a new review

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Meta-Analysis Add a new review Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis Posted By:Ken Havill Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis. Posted By:Gordon S Doig Nutrition support in acute pancreatitis: a systematic review of the literature. Posted By:Gordon S Doig Optimal timing for intravenous administration set replacement. Posted By:Sharon McKinley Insulin therapy for critically ill hospitalised patients Posted By:Laurie Hall Systematic review and meta-analysis of studies of the timing of tracheostomy in adult patients undergoing artificial ventilation. Posted By:Gordon S. Doig Bariatric Surgery: A Systematic Review and Meta-analysis Posted By:Celia Bradford  Concerns regarding quality of included studies  By:Gordon S. Doig  Error regarding mortality rates in diabetic pts  By:Gordon S. Doig Steroids for acute spinal cord injury Posted By:Gordon S. Doig Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature. Posted By:Gordon S. Doig Parenteral vs. enteral nutrition in the critically ill patient: a meta-analysis of trials using the intention to treat principle Posted By:Gordon S. Doig Meta-analysis of parenteral nutrition versus enteral nutrition in patients with acute pancreatitis Posted By:Stephen Drage Ultrasonic locating devices for central venous cannulation: meta-analysis. Posted By:Dr. N. Ramakrishnan Acute renal failure in the intensive care unit: A systematic review of the impact of dialytic modality on mortality and renal recovery. Posted By:brent richards Plasma exchange for Guillain-Barre syndrome Posted By:Gordon S. Doig Venous Thromboembolism and Its Prevention in Critical Care Posted By:A Delaney Deep Vein Thrombosis and Its Prevention in Critically Ill Adults Posted By:A Delaney Adult respiratory distress syndrome: a systemic overview of incidence and risk factors. Posted By:Gordon S. Doig Should Immunonutrition become Routine in Critically Ill Patients? A systematic review of the evidence. Posted By:Gordon S. Doig Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: A meta-analysis Posted By:Sharon McKinley Bleeding and pneumonia in intensive care patients given ranitidine and sucralfate for prevention of stress ulcer:meta-analysis of randomised controlled trials Posted By:Gordon S. Doig Human albumin administration in critically ill Posted By:Gordon S. Doig  initial comments  By:Gordon S. Doig  Wilkes meta-analysis  By:Gord Fluid resuscitation with colloid or crystalloid Posted By:Gordon S. Doig  initial comments  By:Gordon S. Doig

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Diagnosis Add a new review Serum procalcitonin in cerebral ventriculitis Posted By:Celia Bradford Validity of a set of clinical criteria to rule out injury to the cervical spine in patients with blunt trauma Posted By:Todd Fraser Pulmonary embolism detection: prospective evaluation of dual-section helical CT versus selective pulmonary arteriography in 157 patients Posted By:Stephen Drage Accuracy of Clinical Assessment in the Diagnosis of Pulmonary Embolism Posted By:Anthony Delaney Spiral computer tomography for the diagnosis of pulmonary embolism in critically ill surgical patients: A comparison with pulmonary angiography. Posted By:Gordon S. Doig Edit a saved review

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Surrogate Outcomes Add a new review Oral care in the adult intensive care unit Posted By:Sharon McKinley Edit a saved review

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Harm Add a new review Statin therapy is associated with fewer deaths in patients with bacteraemia. Posted By:Gordon S Doig Diuretics and mortality in acute renal failure. Posted By:Gordon S. Doig Diuretics, Mortality, and Nonrecovery of Renal Function in Acute Renal Failure Posted By:A. Delaney  diuretic (frusemide) therapy causing harm  By:dermot phelan The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients Posted By:Gordon S. Doig Edit a saved review

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Therapy Add a new review VASST - Vasopressin versus Norepinephrine Infusion in patients with Septic shock Posted By:Amit Kansal Probiotic prophylaxis in predicted severe acute pancreatitis: Posted By:jonathan field Are daily routine chest radiographs useful in critically ill, mechanically ventilated patients? A randomized study. Posted By:Gordon Doig Hydrocortisone Therapy for Patients with Septic Shock Posted By:Greg Comadira Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. Posted By:Gordon S Doig Norepinephrine plus dobutamine versus epinephrine alone Posted By:jon field Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Posted By:Gordon Doig 12-h pretreatment with methylprednisolone versus placebo for prevention of postextubation laryngeal oedema: a randomised double-blind trial. Posted By:Gordon Doig Levosimendan vs Dobutamine for Patients with acute decompensated heart failure Posted By:jon field Continuous pralidoxime infusion versus repeated bolus Posted By:stuart green L-alanyl-L-glutamine dipeptide-supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: the French controlled, randomized, double-blind, multicenter study. Posted By:K Havill Erythromycin is more effective than metoclopramide in the treatment of feed intolerance in critical illness. Posted By:Gordon S Doig Selenium in Intensive Care (SIC): results of a prospective randomized, placebo-controlled, multiple-center study in patients with severe systemic inflammatory response syndrome, sepsis, and septic shock. Posted By:Gordon S Doig Comparison of Two Fluid-Management Strategies in Acute Lung Injury Posted By:Robert O'Connor  Ventilator free days as an outcome  By:Gordon S Doig Early surgery versus initial conservative treatment in patients with spontaneous supratentorial intracerebral haematomas in the International Surgical Trial in Intracerebral Haemorrhage (STICH): a randomised trial Posted By:George Brieva Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidity Posted By:Laurie Hall Routine changing of intravenous administration sets does not reduce colonization or infection in central venous catheters Posted By:rosalind elliott Prevention of contrast-induced nephropathy with sodium bicarbonate: a randomized controlled trial. Posted By:Gordon S. Doig Antibiotic prophylaxis of early onset pneumonia in critically ill comatose patients. A randomized study. Posted By:Stuart Green U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection Posted By:jon field Effect of intravenous corticosteroids on death within 14 days in 10008 adults with clinically significant head injury (MRC CRASH trial): randomised placebo-controlled trial Posted By:Gordon S. Doig Continuous Positive Airway Pressure for Treatment of Postoperative Hypoxemia: A Randomized Controlled Trial Posted By:Stuart Green The long-term psychological effects of daily sedative interruption on critically ill patients Posted By:Sharon McKinley A comparison of vasopressin and epinephrine for out-of-hospital cardiopulmonary resuscitation Posted By:todd fraser Effect of prone positioning on the survival of patients with acute respiratory failure Posted By:Vatsal Kothari  2nd review  By:Gordon Doig Meropenem (1.5 g/day) is as effective as imipenem/cilastatin (2 g/day) for the treatment of moderately severe intra-abdominal infections. Posted By:Stephen Drage Early goal-directed therapy in the treatment of severe sepsis and septic shock. Posted By:Gordon S. Doig A Clinical Trial of Vena Caval Filters in the Prevention of PE in patients with proximal DVT Posted By:A Delaney Efficacy of Recombinant Human Erythropoietin in Critically Ill Patients: A Randomized Controlled Trial Posted By:Celia Bradford Delaying Defibrillation to Give Basic Cardiopulmonary Resuscitation to Patients With Out-of-Hospital Ventricular Fibrillation A Randomized Trial Posted By:Anthony Delaney Is a low transfusion threshold safe in critically ill patients with cardiovascular disease? Posted By:Gordon S. Doig A multicentere, randomized, controlled clinical trial of transfusion requirements in critical care. Posted By:Gordon S. Doig Low-dose dopamine in patients with early renal dysfunction: a placebo-controlled randomised trial Posted By:Anthony Delaney Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomised trial Posted By:Gordon S. Doig A Randomized, Controlled Trial of the Use of Pulmonary-Artery Catheters in High-Risk Surgical Patients Posted By:A Delaney Efficacy of handrubbing with alcohol based solution versus standard handwashing with antiseptic soap: randomised clinical trial Posted By:Sharon McKinley Oral care in the adult intensive care unit Posted By:Sharon McKinley Dexamethasone in Adults with Bacterial Meningitis Posted By:Todd Fraser Nadroparin in the Prevention of Deep Vein Thrombosis in Acute Decompensated COPD Posted By:A Delaney Effect of intravenous omeprazole on recurrent bleeding after endoscopic treatment of bleeding peptic ulcers Posted By:Caroline Padget Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia. Posted By:Gordon S. Doig Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock Posted By:Julian Castro and Gord Doig Prevention of Radiographic-Contrast-Agent–Induced Reductions in Renal Function by Acetylcysteine Posted By:A Delaney Mild Therapeutic Hypothermia to Improve the Neurologic Outcome after Cardiac Arrest Posted By:Anthony Delaney Daily hemodialysis and the outcome of acute renal failure. Posted By:Gordon S. Doig Intensive Insulin Therapy in Critically ill Patients Posted By:Anthony Delaney Effect of prone positioning on the survival of patients with acute respiratory failure Posted By:Gordon S. Doig  Art Slutsky's editorial  By:Gord Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome Posted By:Gordon S. Doig  Implementation of ARDS net protocol  By:Gord Effect of prolonged methylprednisolone therapy in unresolving ARDS: A randomized controlled trial Posted By:Gordon S. Doig A Comparison of Sucralfate and Ranitidine for the Prevention of Upper Gastrointestinal Bleeding in Patients requiring Mechanical Ventilation Posted By:Dr. Helen Bunting Efficacy and Safety of Recombinant Human Activated Protein C for Severe Sepsis Posted By:Gordon S. Doig

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